PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy
نویسندگان
چکیده
منابع مشابه
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
BACKGROUND In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia. METHODS We performed next-generation sequen...
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Genomic analyses of the myeloid malignancies and clonal disorders of hematopoiesis that may give rise to these disorders have identified that mutations in genes encoding core spliceosomal proteins and accessory regulatory splicing factors are among the most common targets of somatic mutations. These spliceosomal mutations often occur in a mutually exclusive manner with one another and, in aggre...
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Myeloid neoplasms are clonal diseases of hematopoietic stem or progenitor cells that result from molecular alterations that perturb cellular self-renewal, proliferation, and differentiation. As classified by the World Health Organization, myeloid neoplasms include myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), MPN/MDS overlap, and acute myeloid leukemia (AML), which can oc...
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WENTY-FIVE YEARS AGO, William Dameshek, T the founder of this journal and one of the most creative minds in American hematology, raised a provocative question: what do aplastic anemia (AA), paroxysmal nocturnal hemoglobinuria (PNH), and acute leukemia have in common?’ His question was prompted by three observations: (1) the frequency of development of PNH in his own patients with AA, (2) the ov...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2018
ISSN: 1934-5909
DOI: 10.1016/j.stem.2018.10.004